Intended Effect: Pharmaceutical Production (Animals)

goat_001: Transgenic goats engineered to secrete the human protein cholinesterase into their milk produced less milk, with lower fat and lactose levels and unusually high white blood cell counts.

pig_004: Transgenic expression of a mouse milk protein impaired mammary development and function in pigs.

sheep_002: Transgenic sheep had unusually high morbidity and expressed a milk-specific protein in their spleen, liver, and other organs.

Intended Effect: Pharmaceutical Production (Plants)

barley_003: Difficulties were encountered when trying to express human collagen in barley.

tobacco_002: Discoloration and DNA rearrangements were observed in transgenic tobacco plants expressing HIV proteins.