Intended Effect: Pharmaceutical Production

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INTENDED EFFECT: Pharmaceutical Production (Animals)

Goat

Transgenic goats engineered to secrete the human protein cholinesterase into their milk produced less milk, with lower fat and lactose levels and unusually high white blood cell counts.

Pig

Transgenic expression of a mouse milk protein impaired mammary development and function in pigs.

Sheep

Transgenic sheep had unusually high morbidity and expressed a milk-specific protein in their spleen, liver, and other organs.

INTENDED EFFECT: Pharmaceutical Production (Plants)

Barley

Difficulties were encountered when trying to express human collagen in barley.

Tobacco

Discoloration and DNA rearrangements were observed in transgenic tobacco plants expressing HIV proteins.