Type of Unintended Effect: Scrambled DNA

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Arabidopsis

Single-site integration of foreign DNA into Arabidopsis showed rearrangements and deletions of both plant DNA and foreign DNA.

High rate of unintended mutations in Arabidopsis plants genetically engineered with CRISPR/Cas9 method.

Cassava

Using CRISPR-Cas9 to Engineer Resistance to Virus in Cassava Plants Backfires

Corn (Maize)

The transgenic sequences of some Bt maize plants have changed since they were approved.

Humans

After Reported 2018 Birth of Two Genetically-Engineered Babies in China, Calls for Moratorium on Human Germline Engineering Grow

New Studies Fail to End Controversy about How to Interpret Last Year’s Surprise Results in U.S. Human Embryo Research

CRISPR-Cas9, Popular New GMO Tool, Can Cause Extensive Genomic Damage, British Researchers Report

Researchers Agree Human Embryo Experiment Generated Unintended Effects, But Disagree on How to Interpret Surprise Results

Mouse

CRISPR-Cas9, Popular New GMO Tool, Can Cause Extensive Genomic Damage, British Researchers Report

New CRISPR genetic engineering technology caused large number of unintended mutations, researchers in mouse study conclude

Oat

Insertion of transgenes in oats resulted in modification of both the transgenic construct and host DNA.

Tobacco

Discoloration and DNA rearrangements were observed in transgenic tobacco plants expressing HIV proteins.